Barcelona slumped to a 1-0 home defeat by Rayo Vallecano which pushed leaders Real Madrid a step closer to the La Liga title.
Karim Benzema's last-gasp winner sealed Real Madrid's stunning comeback as they recovered from 2-0 down to beat Sevilla 3-2.
Tammy Abraham's penalty more than nine minutes into stoppage time ended Roma’s winless run as Jose Mourinho's scraped a 1-0 victory at 10-man Spezia in Serie A.
Juventus' faint Serie A title hopes were further dented by local rivals Torino, who fought their way back to earn a deserved 1-1 draw in Friday night's Turin derby.
Real Madrid were crowned Spanish Super Cup champions after goals from Luka Modric and Karim Benzema earned them a 2-0 win over Athletic Bilbao.
La Liga champions Atletico Madrid were stunned by Granada, losing 2-1 on Wednesday, while Napoli slipped to defeat against Spezia in Serie A.
Memphis Depay and Philippe Coutinho scored late on at Villarreal as Barcelona won 3-1 to finally end their winless streak away from home under new coach Xavi.
Serie A leaders Napoli lost for the first time this season as Inter Milan reinvigorated their own title bid with a 3-2 win at the San Siro.
Achraf Hakimi struck deep in stoppage time to earn Paris St Germain a 2-1 victory at bottom side Metz and maintain their perfect Ligue 1 record this season.
Pape Matar Sarr has joined Tottenham from French club Metz.
Tottenham have agreed a deal to sign exciting Metz midfielder Pape Matar Sarr for a fee in the region of £14.6m plus add-ons.
Karim Benzema's fine run of form continued with a double as Real Madrid won at Celta Vigo to move up to second place in La Liga.
Lautaro Martinez's late winner stretched Inter's winning run to eight games, while Cristiano Ronaldo answered his critics with a perfect hat-trick.
Timothy Weah and Jonathan David both scored as Lille won 3-0 at Bordeaux on Wednesday to stay top of the French league ahead of Lyon and PSG.
Real Madrid drew level with Atletico Madrid at the top of La Liga with a 2-0 win over Granada, plus all the latest from Serie A and La Liga.
Lionel Messi equalled Pele's record of 643 goals for a single club after scoring for Barcelona against Valencia in La Liga on Saturday.
AC Milan restored their five-point lead at the top of Serie A with a 2-1 win at Sampdoria on Sunday.
Sergio Ramos' late penalty helped secure Real Madrid a 3-2 victory at Real Betis, who finished the La Liga match with 10 men, plus all the latest from around Europe.
Lionel Messi's late penalty edged Barcelona to a 1-0 victory at home to Real Sociedad to ease the pressure on manager Quique Setien.
Barcelona were made to work for their win against third-place Getafe in La Liga on Saturday while PSG were held 4-4 by Amiens in France.