England's star centre Ollie Lawrence has been ruled out of the British and Irish Lions tour to Australia this summer after suffering an Achilles injury.
London Irish administrator Lee Manning says it is only "a matter of time" until the next Premiership club goes bust and that "radical change" is needed.
Saracens missed out on the chance to book a Champions Cup round of 16 home tie as Castres produced a stunning victory in London.
England flanker Sam Underhill is unlikely to play any part in the Six Nations after his club Bath revealed he requires an ankle operation.
Ollie Lawrence has apologised for his role in an incident that led to his England team-mate Alex Mitchell being sin-binned in Bath's defeat at Northampton.
Fin Smith knocked over a last-minute penalty as Northampton beat league leaders Bath 35-34 in a pulsating game of nine tries.
Bath inflicted a record Gallagher Premiership defeat on 14-man Saracens as they powered to a 68-10 victory at the Recreation Ground.
Bristol sent out a major title statement as Pat Lam's men set a new Premiership record in a thumping 54-24 win over Leicester at Welford Road.
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