The Spanish international has been troubled by a long-standing shoulder problem for some time and the club have decided to send him for surgery to clear up the injury.
Xavi has dislocated his shoulder several times in recent matches, but has played through the pain barrier while Barca were still in the Champions League.
Having crashed out of Europe in midweek Barca have felt the time is right to allow Xavi to go under the knife.
Xavi has been forced to pull out of the Spain squad for next week's game with Ecuador and the news is a blow to Barca's hopes of making a late push for Europe.
Better news on the injury front for Barca is that Dutch midfielder Philip Cocu has been given the all-clear to return to action after recovering from a knee ligament injury sustained in February.