Dango Ouattara was the penalty villain for Brentford as his failed Panenka in the shoot-out cost the Bees - and sent West Ham to the FA Cup quarter-finals at their expense.
Manchester City have been drawn against Liverpool in the FA Cup quarter-final, while Chelsea will host League One side Port Vale.
Crowd trouble marred Celtic's dramatic penalty shoot-out victory over Old Firm rivals Rangers which secured them a spot in the Scottish Cup semi-finals.
Leeds reached their first FA Cup quarter-final since 2003 after easing past Championship side Norwich with a 3-0 victory at Elland Road.
Pep Guardiola will receive a two-game touchline ban after the Manchester City boss was booked for the sixth time this season during the FA Cup win over Newcastle.
Port Vale produced one of the great FA Cup shocks as the League One basement side stunned Premier League Sunderland 1-0 to book their place in the quarter-finals.
Fulham crashed out of the FA Cup following a 1-0 home defeat to Southampton in a fifth-round tie that was overshadowed by a controversial performance from referee Jarred Gillett.
Man City booked their place in the FA Cup quarter-finals with a thrilling 3-1 comeback win at Newcastle on Saturday night.
Wrexham were denied a dramatic goal in extra-time by VAR with Alejandro Garnacho and Joao Pedro securing an unconvincing 4-2 win to book Chelsea's place in the FA Cup quarter-finals.
Arsenal survived a major scare against League One Mansfield to progress through to the FA Cup quarter-finals and keep their hopes of a quadruple alive.
Phil Parkinson criticised VAR in Wrexham's first encounter with the system during the dramatic 4-2 loss to Chelsea in the fifth round of the FA Cup.
Liverpool bounced back from their recent defeat to Wolves with a 3-1 win at Molineux to progress to the quarter-finals of the FA Cup.
Mansfield may have beaten Championship Sheffield United and Premier League Burnley in the last two rounds of the FA Cup, but it is another game in the run that stands out for Town boss Nigel Clough.
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Macclesfield Town were unable to recreate the magic of last month's FA Cup win over holders Crystal Palace, with a Sam Heathcote own goal sending Brentford through to the fifth round after a spirited contest at Moss Rose.
League One Mansfield Town will host Premier League leaders Arsenal, while Manchester City face a tricky-looking trip to Newcastle United in the fifth round of the FA Cup.
Keep, reform or remove. We are approaching a crossroads with VAR - and there is a big debate about how we move forward.
Sean Longstaff scored the winning spot-kick as Leeds edged through to the last 16 of the FA Cup by beating Birmingham 4-2 on penalties after it had finished 1-1 after extra time.
Harrison Reed's opportunistic finish carried Fulham into the fifth round of the FA Cup as they came from behind to beat Stoke 2-1.
Sunderland reached the FA Cup fifth round for the first time since 2015 as Habib Diarra's contentious first-half penalty earned a 1-0 win away to Oxford United.
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