Riyad Mahrez, Sadio Mane and Eric Bailly are among the Premier League stars expected to be called up for the 2017 Africa Cup of Nations at the start of next year.
The final round of qualifying matches took place over the weekend, with the 16-team tournament kicking off in Gabon on January 14 and ending with the final on February 5.
It's bad news for a number of Premier League sides, with a host of players expected to take part and potentially miss up to a month of domestic action which includes four rounds of league fixtures.
Based on recent call-ups, champions Leicester are likely to be the most affected side. Claudio Ranieri faces the prospect of losing four players - Algeria duo Riyad Mahrez and Islam Slimani, and Ghana's Jeffrey Schlupp and Daniel Amartey - for a run of games that includes clashes with Chelsea, Southampton and Manchester United.
The Foxes are not the only title contenders who could suffer, with United's Eric Bailly, Liverpool's Sadio Mane and Arsenal's Mohamed Elneny likely to take part for Ivory Coast, Senegal and Egypt.
Stoke, Sunderland, Watford and West Ham could lose three players each, including Wilfried Bony, Lamine Kone (both Ivory Coast), Adlene Guedioura (Algeria) and Andre Ayew (Ghana) respectively.
Everton will have to cope without new signings Yannick Bolasie and Idrissa Gueye, who represent DR Congo and Senegal, while Southampton could lose their newly-recruited Morocco international Sofiane Boufal.
Burnley, Chelsea, Manchester City, Middlesbrough, Swansea and Tottenham are the only Premier League sides likely to be unaffected. Read on for the full list…
Arsenal
Mohamed Elneny - Egypt
Bournemouth
Max Gradel - Ivory Coast
Crystal Palace
Pape Souare - Senegal
Bakary Sako - Mali
Everton
Idrissa Gueye - Senegal
Yannick Bolasie - DR Congo
Hull
Ahmed Elmohamady - Egypt
Leicester
Riyad Mahrez - Algeria
Islam Slimani - Algeria
Jeffrey Schlupp - Ghana
Daniel Amartey - Ghana
Liverpool
Sadio Mane - Senegal
Manchester United
Eric Bailly - Ivory Coast
Southampton
Sofiane Boufal - Morocco
Stoke
Mame Biram Diouf - Senegal
Ramadan Sobhi - Egypt
Wilfried Bony - Ivory Coast
Sunderland
Didier Ndong - Gabon
Lamine Kone - Ivory Coast
Wahbi Khazri - Tunisia
Watford
Nordin Amrabat - Morocco
Adlene Guedioura - Algeria
Brice Dja Djedje - Ivory Coast
West Brom
Allan Nyom - Cameroon
West Ham
Sofiane Feghouli - Algeria
Cheikhou Kouyate - Senegal
Andre Ayew - Ghana