Ephron Mason-Clark and Kwame Poku led Peterborough on a local-derby destruction as they beat Cambridge 5-0.
Darren Ferguson's men stung the visitors with a three-goal blitz in the space of six minutes to set themselves on the way to a biggest-ever success against their county rivals.
Mason-Clark provided the 34th-minute opener with a diving header after a sumptuous cross from the right by Poku and the celebrations had barely died down when Mason-Clark struck again with a 37th-minute tap in after Ricky-Jade Jones fired the ball across the face of goal.
And Posh still were not done there as Poku darted inside from the right and unleashed a 20-yard strike which took a wicked deflected off defender Michael Morrison and flew over the stranded Jack Stevens after 40 minutes.
Things got even worse for Cambridge in the second period when Joel Randall's pass allowed Poku to strike again in the 54th minute after an Archie Collins-led counter-attack stemming from the visitors' own corner.
And Posh completed a famous five when Randall's 86th-minute cross following a short-corner was headed into his own net by Cambridge full-back Liam Bennett.