West Ham manager Slaven Bilic says Enner Valencia is facing another four weeks on the sidelines as his injury problems continue.
Valencia has already missed three months of the season after suffering an ankle injury against Astra in the Europa League qualifier in July.
He returned in October against Watford but suffered another ankle injury after coming on as a substitute in the 1-1 draw with Everton prior to the international break.
Dimitri Payet has already been ruled out for three months, although surgery has been ruled out for the French playmaker, and Bilic admits Valencia now faces another spell on the sidelines.
Bilic said: "We had another blow with Enner Valencia. We were without him since Astra and he came on against Everton and was really good.
"To be without him again is a massive blow. His injury looks like four weeks, which is not that long, but long enough."
West Ham have surprised many with their enterprising start to the season and are in sixth place after only one defeat in their last nine.
Speaking ahead of Sunday's game against Tottenham, which you can see live on Sky Sports, Bilic is keen to curb expectations, saying: "It's November and December when things can change around, but we are approaching this period with our eyes wide open.
"We are in a good position, but it's only a start. It's good to have a good amount of points and you are confident."
Bilic is also without another star man - Dimitri Payet - for the trip to White Hart Lane but Diafra Sakho returns to the squad this weekend.
The manager said: "You don't have to be West Ham manager to say he is really important. Dimitri Payet is our best player.
"His impact on not only us but the Premier League is huge. He is very important in terms of scoring goals, assets or keeping the ball. We are going to miss him. It was simply a very bad tackle. He is irreplaceable.
"That is why he is Payet, he is one of those players making the team better 50 per cent. It is a question mark to me to see how we will look without him.
"We have a lot of quality players and the players have to step up and do more for us to feel his absence less than huge. It is a big blow. It'll be nine, 10 or 12 weeks. I have spoken to him a few times and he is a very strong character."