Newcastle United have confirmed Jonas Gutierrez and Ryan Taylor will not be offered new contracts and will leave the club this summer.
Gutierrez has been with Newcastle since 2008 and, after making a recovery from testicular cancer, played a starring role in keeping the club in the Premier League this season.
The Argentina international midfielder set up the opening goal for Moussa Sissoko and then scored their second in the final day 2-0 win over West Ham that secured their top-flight status.
He made 205 appearances for the club and scored 12 goals.
Taylor played 110 times for Newcastle and scored 10 times after joining from Wigan in 2009, but his time on Tyneside was blighted by a pair of serious knee ligament injuries.
Both players will become free agents when their deals expire on June 30.
The club's managing director Lee Charnley said: "Ryan and Jonas have both contributed significantly to Newcastle United over a number of years and on behalf of the board, I would like to place on record our sincere thanks to both players for the excellent service they have given the club.
"It was a great pleasure to see Ryan and Jonas come back into the team in recent weeks and compete at the highest level after the injury and illness battles they have had to overcome.
"To come through those difficult periods with such strength and dignity will have given hope and inspiration to many and it is clear that our supporters have a deep connection and affection for both players, as does everyone associated with the club."
Newcastle have also released Jak Alnwick, Adam Campbell and Remie Streete, while Facundo Ferreyra has returned to Shakhtar Donetsk at the end of his loan.
However, the club have revealed a new deal has been offered to forward Sammy Ameobi.
The 23-year-old academy graduate, younger brother of former United striker Shola, played 25 Premier League matches for the Magpies last term and is out of contract at the end of June.