Chelsea started their Women's Champions League campaign with a 5-0 first-leg win over SFK 2000 in their last-32 tie in Sarajevo on Wednesday.
Millie Bright, Drew Spence and Maria Torrisdottir gave the Women's Super League champions a commanding half-time lead, with Ji So-Yun and Adelina Engman adding further goals late in the game.
Chelsea, WSL title and FA Cup double winners last season, were in control from the first whistle and could have won by a bigger margin, with Fran Kirby seeing her 81st-minute penalty saved.
Glasgow City Ladies secured their first-ever away win in the competition's knockout stage with a 2-0 win against Somatio Barcelona in Limassol.
Hayley Lauder gave the Scottish champions a flying start and Leanne Crichton made sure of victory with a late second against the Cypriots.
Both sides finished the game with 10 players, with Somatio skipper Rita Akaffou sent off for two yellow cards just before half-time and City captain Leanne Ross dismissed for her second booking early in the second period.
Manchester City get their Champions League campaign underway in Spain on Thursday against Atletico Madrid.