Steven Bergwijn starts for Tottenham against Man City on Saturday Night Football, with Gareth Bale on the bench, while Raheem Sterling and Sergio Aguero are also on the City bench.
Netherlands forward Bergwijn scored on his Spurs debut in the corresponding fixture last year but missed the international break due to an unspecified injury.
That means Gareth Bale drops to the bench for Spurs.
Erik Lamela (Achilles) doesn't make the squad, while Matt Doherty is self-isolating after testing positive for Covid-19 while on international duty with the Republic of Ireland.
For City, Sterling and Aguero both start on the bench as they fail to fully recover; Aguero has been out for the past month with a hamstring injury and Sterling pulled out of the England squad earlier this week with a calf problem.
Joao Cancelo starts at left-back, Gabriel Jesus once again starts up front, with Ferran Torres and Riyad Mahrez either side of him.
Bernardo Silva also starts, with Ilkay Gundogan and Phil Foden on the bench.
City skipper Fernandinho, recently sidelined with a muscular injury, is now out after suffering gastroenteritis, while defenders Nathan Ake and Benjamin Mendy also don't make the squad.
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Tottenham: Lloris, Aurier, Alderweireld, Dier, Reguilon, Hojbjerg, Sissoko, Ndombele, Son, Bergwijn, Kane
Subs: Hart, Bale, Rodon, Lo Celso, Moura, Davies, Vinicius
Man City: Ederson, Walker, Dias, Laporte, Cancelo, Rodrigo, Bernardo Silva, De Bruyne, Mahrez, Torres, Jesus
Subs: Steffen, Stones, Sterling, Gundogan, Aguero, Foden, Garcia
How to follow
Tottenham vs Man City will be broadcast live on Sky Sports Premier League from 5pm on Saturday Night Football; kick-off at 5.30pm.
Sky Sports customers can watch in-game clips in the live match blog on the Sky Sports website and app.
Highlights will also be published on the Sky Sports digital platforms and the Sky Sports Football YouTube channel shortly after the final whistle.
Watch the Premier League live on Sky Sports
At least 146 Premier League games will be shown live on Sky Sports in the 2020/21 season. The Premier League has further increased the number of televised games this season from 200 to 231, with over half of the extra fixtures set to be shown live on Sky Sports.
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Overall, Sky Sports will be showing at least 146 Premier League matches live throughout the 2020/21 season, continuing to bring you all the latest twists, turns and shocks at the home of the Premier League.
There will also be two additional midweek programmes - one will be played across the weeks commencing January 11 and 18 and the second will be in the week commencing May 10. All of these games will be broadcast live.
You can also follow the action with our dedicated live blogs on the Sky Sports website and app, and watch free match highlights from every game shortly after full-time on our digital platforms and YouTube channel.
Pitch to Post Preview podcast: Smith on Pep's City contract and Arsenal's issues
Alan Smith joins Peter Smith on this week's Pitch to Post Preview Podcast to discuss Pep Guardiola's new Man City contract, Tottenham's title hopes and what's going wrong at Arsenal.
Plus, Sky Sports News reporter Vinny O'Connor has the latest on Liverpool's growing injury list ahead of their clash with Leicester, and his colleague Mark McAdam lifts the lid on Southampton's strong start to the season.
Plus Sky Sports football journalist Ron Walker talks Leicester and West Ham, and makes his Pitch for what will happen in the Premier League this weekend.
Download the Sky Sports Pitch to Post Podcast on Apple | Spotify